Monoclonal Antibody to CD45RO (Clone: C45.1)
Product Sizes
25ug
£319.00
10-7509-25UG
100ug
£456.00
10-7509-100UG
About this Product
- SKU:
- 10-7509
- Additional Names:
- PTPRC||CD45
- translate.label.attr.clone:
- C45.1
- Clonality:
- Monoclonal
- Extra Details:
- The CD45RA and CD45RO isoforms of the leukocyte common antigen identify functionally distinct naive and memory T cell subsets. In vitro, CD45RA+ / CD45RO - peripheral blood lymphocytes (PBL) can be converted to CD45RA- / CD45RO + phenotype upon activation in the presence of IL-2. Both CD3+ and CD3-/CD56+ lymphocyte subsets can be converted to CD45RO + lymphocytes. Expression of CD45RO was observed only in response to IL-2 and was not observed during long-term culture in IL-4, IL-6, or IL-7. This antibody recognizes an 180kDa protein, identified as isoform of leukocyte common antigen (CD45RO). This antibody reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. Shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. Though this antibody is useful to identify T-cell lymphomas and leukemia, rare staining with B cell lymphomas reported.
- Format:
- Purified
- Gene Details:
- PTPRC
- Host:
- Mouse
- Immunogen:
- Interleukin-2-dependent human T lymphocytes were used as the immunogen for the CD45RO antibody.
- Isotype:
- Mouse IgG2a Kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
