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Antibodies

Monoclonal Antibody to DNMT2 (Clone: ABM1H70)

Product Sizes
25ug
£319.00
10-7010-25UG
100ug
£429.00
10-7010-100UG
About this Product
SKU:
10-7010
Additional Names:
DNA (cytosine-5)-methyltransferase-like protein 2; DNA methyltransferase homolog HsaIIP; DNMT2
translate.label.attr.clone:
ABM1H70
Clonality:
Monoclonal
Extra Details:
DNMT2, also known as tRNA-aspartic acid methyltransferase 1 (TRDMT1), is highly conserved cytosine-C5 methyltransferase that introduces the C38 methylation of tRNAAsp in many species, including lower eukaryotes, plants, insects, and humans. DNMT2 contains all 10 sequence motifs that are conserved among m5C MTases, including the consensus S-adenosyl-L-methionine-binding motifs and the active site ProCys dipeptide. It is a relatively small protein of 391 amino acids and lacks the large N-terminal domains present in the DNMT1 and DNMT3 families. DNMT2 is ubiquitously expressed with multiple mRNA species in most human and mouse adult tissues. It is variably expressed in human cancer cell lines.
Format:
Purified
Gene Details:
TRDMT1
Host:
Mouse
Immunogen:
A partial length recombinant protein from DNMT2 was used as the immunogen for this antibody.
Isotype:
Mouse IgG1, Kappa
Purification:
Protein G Chromatography
Reactivities:
Human, Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig-2: Intracellular Flow analysis of DNMT2 antibody in Hela cells using 0.5 µg/ 10^6 cells of anti-DNMT2 antibody (ABM1H70). Green represents isotype control; red represents anti-DNMT 2 antibody. Goat anti-mouse PE conjugate was used as secondary antibody. (Cells were fixed with 4% paraformaldehyde for 10 min and washed with PBS by centrifuging at 1100 for 5 min followed by permeabilization for 20 min and washed again as mentioned above. Then cell were incubated with primary antibody for 45
Fig-2: Intracellular Flow analysis of DNMT2 antibody in Hela cells using 0.5 µg/ 10^6 cells of anti-DNMT2 antibody (ABM1H70). Green represents isotype control; red represents anti-DNMT 2 antibody. Goat anti-mouse PE conjugate was used as secondary antibody. (Cells were fixed with 4% paraformaldehyde for 10 min and washed with PBS by centrifuging at 1100 for 5 min followed by permeabilization for 20 min and washed again as mentioned above. Then cell were incubated with primary antibody for 45