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Antibodies

Monoclonal Antibody to MBD2/MBD3 (Clone: ABM14A8)

Product Sizes
25ug
£319.00
10-7006-25UG
100ug
£429.00
10-7006-100UG
About this Product
SKU:
10-7006
Additional Names:
MBD3
translate.label.attr.clone:
ABM14A8
Clonality:
Monoclonal
Extra Details:
MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. This protein binds around 1 kb downstream of the transcription start site of a subset of  400 CpG island promoters that are characterized by the presence of active histone marks, RNA polymerase II (Pol2) and low to medium gene expression levels and H3K36me3 deposition. Methylated MBD2 is involved in silencing methylated tumor suppressor genes as well as activation of pro-metastatic genes. MBD2 also plays a key role in regulating expression of a range of genes that are associated with optimal DC (Dendritic cells) activation and function.
Format:
Purified
Gene Details:
MBD3
Host:
Mouse
Immunogen:
A partial length recombinant MBD3 protein (amino acids 1-290) was used as the immunogen for this antibody.
Isotype:
Mouse IgG1 Kappa
Purification:
Protein G Chromatography
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig-2 : Immunohistochemical analysis of MBD3 in human breast tissue using MBD3 antibody (Clone: ABM14A8) at 5 µg/ml.
Fig-3 : Immunohistochemical analysis of MBD3 in human Kidney tissue using MBD3 antibody (Clone: ABM14A8) at 10 µg/ml.
Fig-4 : Immunohistochemical analysis of MBD3 in human Testis tissue using MBD3 antibody (Clone: ABM14A8) at 10 µg/ml.
Fig-4 : Immunohistochemical analysis of MBD3 in human Testis tissue using MBD3 antibody (Clone: ABM14A8) at 10 µg/ml.
Fig-5: Intracellular flow analysis of MBD2/MBD3 in Jurkat cells using 0.5 µg/10^6 cells of MBD2/MBD3 antibody (Clone: ABM14A8). Green represents isotype control; red represents anti-MBD2/MBD3 antibody. Goat anti-mouse PE conjugate was used as secondary antibody.