Monoclonal Antibody to Dnmt1 (Clone: ABM13B2)
Product Sizes
25ug
£319.00
10-7002-25UG
100ug
£429.00
10-7002-100UG
About this Product
- SKU:
- 10-7002
- Additional Names:
- DNMT1||AIM||CXXC9||DNMT
- translate.label.attr.clone:
- ABM13B2
- Clonality:
- Monoclonal
- Extra Details:
- Dnmt1(DNA (cytosine-5-)-methyltransferase 1 ) is one of the most abundant DNA methyltransferase in mammalian tissues, where it associates with the replication machinery and restores symmetrical methylation at hemimethylated CpG sites generated by the semi-conservative DNA replication process. Dnmt1 comprises a regulatory N-terminal region and a C-terminal catalytic domain connected by a linker of seven glycine-lysine repeats. The N-terminal part contains a PCNA binding domain (PBD), a heterochromatin targeting sequence (TS), a CXXC-type zinc finger domain and two Bromo-Adjacent Homology domains (BAH1 and BAH2). The C-terminal domains of mammalian Dnmts contain all ten catalytic motifs identified in bacterial DNA (cytosine-5) methyltransferases. Dnmt1 maintains methylation patterns with high fidelity and is essential for embryonic development and genome integrity. The molecules interacting with Dnmt1, including RNA polymerase II, some RNA-binding proteins, and some specific Dnmt1-inhibitory RNA molecules are involved in chromatin organization, DNA repair, cell cycle regulation, and apoptosis.
- Format:
- Purified
- Gene Details:
- DNMT1
- Host:
- Mouse
- Immunogen:
- A partial length recombinant DNMT1 protein (amino acids 128-429) was used as the immunogen for this antibody.
- Isotype:
- Mouse IgG1 Kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
