Monoclonal antibody to CD46 (Clone: TRA-2-10)
Product Sizes
25ug
£319.00
10-4203-25UG
100ug
£429.00
10-4203-100UG
About this Product
- SKU:
- 10-4203
- Additional Names:
- TLX; Trophoblast leukocyte common antigen; MCP; MIC10
- Application:
- ELISA
- translate.label.attr.clone:
- TRA-2-10
- Clonality:
- Monoclonal
- Extra Details:
- CD46 is a transmembrane protein that serves several functions, including as a complement membrane cofactor protein (MCP) and a receptor to the measles virus. CD46 is widely expressed on leukocytes, platelets, epithelial cells, and fibroblasts. There are multiple reported isoforms of CD46 with molecular weights ranging from 45 to 75 kD. The CD46 protein binds and inactivates the complement components C3b and C4b and ahs also been reported to play a role in T cell regulation. In addition, CD46 has been shown to interact with other proteins, including moesin, c-SRC, tetraspanin 4, c-Yes, and integrin delta²1. CD46 also acts as a cellular receptor for human herpes virus-6 and human measles virus, in addition to other pathogens such as Streptococcus pyogenes. Defective CD46 has been associated with hemolytic-uremic syndrome.
- Format:
- Purified
- Gene Details:
- CD46
- Host:
- Mouse
- Immunogen:
- Human embryonal carcinoma cell line 2102Ep was used as the immunogen for this antibody.
- Isotype:
- Mouse IgG1
- Purification:
- Protein G Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:10-4203.png
