Monoclonal Antibody to CLEC4E (Clone: ABM42C6)
Product Sizes
25ug
£319.00
10-4120-25UG
100ug
£429.00
10-4120-100UG
About this Product
- SKU:
- 10-4120
- Additional Names:
- CLEC4E||CLECSF9||MINCLE||UNQ218/PRO244
- translate.label.attr.clone:
- ABM42C6
- Clonality:
- Monoclonal
- Extra Details:
- CLEC4E (C-type lectin domain family 4, member E), also called as Mincle, is a type II transmembrane C-type lectin receptor that specifically binds to the cord factor TDM (trehalose-6,6-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activates immune cells to confer adjuvant activity. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. CLEC4E is mainly expressed in myeloid cells, such as macrophages and neutrophils and possesses a single carbohydrate-recognition domain (CRD) in the extracellular region. It is associated with FcRgamma chain, an immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor, and acts as an activating receptor that senses damaged cells. CLEC4E is also a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPbeta) and may play a role in inflammation.
- Format:
- Purified
- Gene Details:
- CLEC4E
- Host:
- Mouse
- Immunogen:
- A full length human CLEC4E protein was used as the immunogen for this antibody.
- Isotype:
- Mouse IgG1 Kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
