Monoclonal Antibody to IL-3RA (Clone: ABM25C1)
Product Sizes
25ug
£319.00
10-4027-25UG
100ug
£429.00
10-4027-100UG
About this Product
- SKU:
- 10-4027
- Additional Names:
- Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; CD123; IL-3R-alpha
- translate.label.attr.clone:
- ABM25C1
- Clonality:
- Monoclonal
- Extra Details:
- Interleukin-3 receptor subunit alpha (IL-3RA) or CD123 is a high-affinity receptor for interleukin-3 (IL-3), which along with the primary signaling commonbeta(delta²c) subunit (CD131) forms a heterodimer, enabling cell signaling. IL-3RA chain is a glycoprotein of 360 amino acidic residues, composed by an extracellular domain of 287 amino acid residues, involving a predicted Ig-like domain, two Fn III domains, a transmembrane domain of 30 amino acid residues and by an intracellular domain of 53 residues. It is expressed on the majority of CD34+ hemopoietic progenitors and its expression is rapidly lost during erythroid and megakaryocytic differentiation, moderately decreased during monocytic differentiation and is sustained in the granulocytic lineage. IL-3RA is also expressed in a variety of hematological neoplasms including blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), Hodgkin–s lymphoma and hairy cell leukemia.
- Format:
- Purified
- Gene Details:
- IL3RA
- Host:
- Mouse
- Immunogen:
- A partial length recombinant protein (a.a 120-323) of IL-3RA was used as the immunogen for this antibody.
- Isotype:
- Mouse IgG2b, Kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
