Monoclonal Antibody to mouse CD180 (Clone: RP/14)
Product Sizes
500 µg
£2020.00
10-3502-500UG
About this Product
- SKU:
- 10-3502
- Additional Names:
- CD180 antigen; Lymphocyte antigen 78; Ly-78; Radioprotective 105 kDa protein
- translate.label.attr.clone:
- RP/14
- Clonality:
- Monoclonal
- Extra Details:
- Radioprotective 105 (RP105; CD180) is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105; assigned as CD180; is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105; CD180) expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis; B-cell proliferation; and up-regulation of a costimulatory molecule B7.2; revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1; which is in this context important for RP105 with respect to B-cell surface expression and LPS recognition and signalling. MD-1 seems to be requisite for efficient expression of RP105.
- Format:
- Purified
- Host:
- Mouse
- Isotype:
- Rat IgG2a; Kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
