Monoclonal Antibody to NALP3 (Clone: ABM2D48)
Product Sizes
25ug
£319.00
10-3018-25UG
100ug
£429.00
10-3018-100UG
About this Product
- SKU:
- 10-3018
- Additional Names:
- NLRP3||C1orf7||CIAS1||NALP3||PYPAF1
- translate.label.attr.clone:
- ABM2D48
- Clonality:
- Monoclonal
- Extra Details:
- NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein protein interaction, an intermediate nucleotide binding self oligomerization NACHT domain and a C-terminal domain containing leucine rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kB signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.
- Format:
- Purified
- Gene Details:
- NLRP3
- Host:
- Mouse
- Immunogen:
- A partial length recombinant NALP3 protein (amino acids 150-385) was used as the immunogen for this antibody.
- Isotype:
- Mouse IgG2b Kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
