Monoclonal Antibody to Mouse TLR3 (Clone: ABM24E5)
Product Sizes
25ug
£319.00
10-3017-25UG
100ug
£429.00
10-3017-100UG
About this Product
- SKU:
- 10-3017
- Additional Names:
- Tlr3
- translate.label.attr.clone:
- ABM24E5
- Clonality:
- Monoclonal
- Extra Details:
- Mouse Toll-like receptor 3 (mTLR3) belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a molecular pattern associated with viral infections. It has seven exons. mTlr3 show high homology to hTLR3 in their predicted cDNA and protein sequences. The intracellular region of mTlr3 has remarkable homology with the same region of others mTlrs. mTlr3 mRNA is ubiquitously expressed in tissues, being expressed highest in spleen, kidney and lung. Its activation by the synthetic ligand polyinosine:polycytidylic acid (poly I:C) or by mRNA rapidly causes growth cone collapse and irreversibly inhibits neurite extension independent of NF-kappaB. The high levels of mTlr3 expression in Mz B cells perhaps contribute to their ability to clear antigen from the blood.
- Format:
- Purified
- Gene Details:
- Tlr3
- Host:
- Rat
- Immunogen:
- A partial length recombinant mTLR3 protein (amino acids 180-385) was used as the immunogen for this antibody.
- Isotype:
- Rat IgG2b Kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:mouse brain.jpg
