Recombinant Anti-TNFa (Adalimumab biosimilar) mAb
Product Sizes
100ug
£529.00
10-2008-100UG
About this Product
- SKU:
- 10-2008
- Additional Names:
- Cachectin; TNF-alpha; TNFA; TNFSF2; Tumor necrosis factor ligand superfamily member 2 (TNF-a)
- Clonality:
- Monoclonal
- Extra Details:
- SOURCE: Chinese Hamster Ovary Cells (CHO). Adalimumab belongs to the pharmacotherapeutic group –immunosuppressants, tumour necrosis factor alpha (TNF-alpha) inhibitors– (ATC code: L04AB04). The mechanism of action of adalimumab is binding specifically to TNF-alpha and neutralising its biological function by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab is a recombinant human IgG1 monoclonal antibody composed of two kappa light chains each with a molecular weight of approximately 24 kilo Daltons (kDa) and two IgG1 heavy chains each with a molecular weight of approximately 49 kDa based on the amino acid sequence. The total molecular weight of adalimumab with post-translational modifications is approximately 148 kDa. Each light chain consists of 214 amino acid residues and each heavy chain consists of 451 amino acid residues resulting in a total of 1330 amino acids for the entire IgG1 molecule; one glycosylation site (N301) is present. The primary amino-acid sequence of the heavy and light chains is reported.
- Gene Details:
- TNFA
- Isotype:
- Human IgG1, kappa
- Purification:
- Greater than 98.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Please avoid freeze thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
