Monoclonal Antibody to Mouse Noxa (Clone: ABM46B8)
Product Sizes
25ug
£319.00
10-1057-25UG
100ug
£429.00
10-1057-100UG
About this Product
- SKU:
- 10-1057
- Additional Names:
- Phorbol-12-myristate-13-acetate-induced protein 1
- translate.label.attr.clone:
- ABM46B8
- Clonality:
- Monoclonal
- Extra Details:
- Noxa is a BH3-only pro-apoptotic protein that mediates apoptosis by specifically inhibiting the anti-apoptotic Bcl-2 family member Mcl-1. It consists of 54 amino acids with one BH3 domain. The gene for NOXA is a target of p53. In response to cellular stress Noxa is induced by p53 and mediates p53-induced apoptosis. But more recently, it has been shown that NOXA can also be induced independently of p53 by other transcription factors such as p73 and E2F1. Noxa is also found to be induced by hypoxia-inducible factor (HIF-1) and mediates HIF-1 induced hypoxic cell death. Noxa is commonly upregulated in melanomas, and is associated with melanoma development and progression. Increase in Noxa expression is driven by oncogenic activation of MEK/ERK signaling through the transcription factor CREB (cAMP responsive element binding protein).
- Format:
- Purified
- Gene Details:
- Pmaip1
- Host:
- Rat
- Immunogen:
- A full length recombinant mNOXA protein was used as the immunogen for this antibody.
- Isotype:
- Rat IgG2b, kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
