Monoclonal Antibody to Bcl-2 (Clone: BC1)
Product Sizes
25ug
£319.00
10-1052-25UG
100ug
£429.00
10-1052-100UG
About this Product
- SKU:
- 10-1052
- Additional Names:
- BCL2
- translate.label.attr.clone:
- BC1
- Clonality:
- Monoclonal
- Extra Details:
- Bcl-2 (B-cell lymphoma 2), is a member of Bcl-2 family of regulator proteins. These proteins contain a hydrophobic cleft that binds to BH3-only proteins and to the pro-apoptotic Bcl-2 family members Bad, Bak, and Bax to inhibit apoptosis. In the absence of this binding, the proapoptotic Bcl-2 members are recruited to the OMM (Outer Mitochondrial Membrane) at which they oligomerize and cause OMM permeabilization, releasing proapoptotic effectors such as SMAC or cytochrome-c. Bcl-2 also neutralize a group of 'sensor' proteins (such as BIM), which are triggered by cytotoxic stimuli such as chemotherapy. BCL-2 proteins therefore have a central role as guardians against apoptosis, helping cancer cells to evade cell death.
- Format:
- Purified
- Gene Details:
- BCL2
- Host:
- Mouse
- Immunogen:
- A synthetic peptide corresponding to amino acids 41-54 (GAAPAPGIFSSQPG-Cys); of human Bcl-2 was used as immunogen.
- Isotype:
- Mouse IgG1 Kappa
- Purification:
- Protein G Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
