Monoclonal Antibody to Caspase-8 (Clone: ABM14C1)
Product Sizes
25ug
£319.00
10-1019-25UG
100ug
£429.00
10-1019-100UG
About this Product
- SKU:
- 10-1019
- Additional Names:
- Apoptotic cysteine protease; Apoptotic protease Mch-5; FADD-homologous ICE/ced-3-like protease; CE-like apoptotic protease 5
- translate.label.attr.clone:
- ABM14C1
- Clonality:
- Monoclonal
- Extra Details:
- Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18.The Active/Cleaved Caspase-8 polyclonal antisera recognizes the large and small subunits of active/cleaved caspase-8. Whereas the antisera has a strong preference for active/cleaved caspase-8, in some cell or tissue systems or techniques the antisera may also recognize the proform of caspase-8 as well as intermediate caspase-8 cleavage fragments.
- Format:
- Purified
- Gene Details:
- CASP8
- Host:
- Mouse
- Immunogen:
- A partial length recombinant protein (a.a 179-385) of Caspase-8 was used as the immunogen for this antibody.
- Isotype:
- Mouse IgG1
- Purification:
- Protein G Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
