Monoclonal Antibody to Caspase-3 (Clone: ABM11D3)
Product Sizes
25ug
£319.00
10-1004-25UG
100ug
£429.00
10-1004-100UG
About this Product
- SKU:
- 10-1004
- Additional Names:
- Apopain; Cysteine protease CPP32; SREBP cleavage activity; SCA-1
- translate.label.attr.clone:
- ABM11D3
- Clonality:
- Monoclonal
- Extra Details:
- Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death. Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis.
- Format:
- Purified
- Gene Details:
- CASP3
- Host:
- Mouse
- Immunogen:
- Full length recombinant protein of Caspase-3 was used as the immunogen for this antibody.
- Isotype:
- Mouse IgG1
- Purification:
- Protein G Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:anti-caspase3-abm11de-flow.jpg
