Recombinant Human Ubiquitin thioesterase L1/UCHL1 protein
Product Sizes
10 ug
£115.00
RP03231-10UG
20 ug
£145.00
RP03231-20UG
50 ug
£193.00
RP03231-50UG
100 ug
£276.00
RP03231-100UG
500 ug
£764.00
RP03231-500UG
1000 ug
£1193.00
RP03231-1000UG
About this Product
- SKU:
- RP03231
- Additional Names:
- UCHL1,Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC:3.4.19.12, Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1
- Extra Details:
- Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis by the ubiquitin pathway has been implicated in control of the cell cycle, transcriptional activation, cell fate and growth, and synaptogenesis. The ubiquitin-proteasome system is involved in synaptic plasticity and is proposed to be part of a molecular switch that converts short-term synaptic potentiation to long-term changes in synaptic strength. UCHL1 is found in neuronal cell bodies and processes throughout the neocortex (at protein level). It is expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. UCHL1 is weakly expressed in ovary. UCHL1 is a ubiquitin-protein hydrolase. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. UCHL1 dysfunction has been associated with neurodegeneration in Parkinson's, Alzheimer's, and Huntington's disease patients. Reduced UCHL1 function may jeopardize the survival of CNS neurons.
- Formulation:
- Recombinant Human Ubiquitin thioesterase L1/UCHL1 protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Ala223)of Human Ubiquitin thioesterase L1/UCHL1
- Immunogen:
- Met1-Ala223
- Molecular Weight:
- 26-30 kDa
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Sequence:
- MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
- Manufacturer's Data Sheet:RP03231
