Recombinant Human GAS-6 Protein
Product Sizes
10 ug
£193.00
RP02964-10UG
20 ug
£258.00
RP02964-20UG
50 ug
£383.00
RP02964-50UG
100 ug
£586.00
RP02964-100UG
500 ug
£1716.00
RP02964-500UG
1000 ug
£2716.00
RP02964-1000UG
About this Product
- SKU:
- RP02964
- Additional Names:
- GAS6, AXLLG,Growth arrest-specific protein 6, GAS-6, AXL receptor tyrosine kinase ligand
- Extra Details:
- GAS-6 is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest . Gas6 and the structurally related Protein S are vitamin K-dependent and have an extensively gamma -carboxylated N-terminal Gla domain, four EGF-like repeats, and a C-terminal region with homology to steroid hormone binding globulin (SHBG) . Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer . Human Gas6 interacts with both mouse and rat orthologs of these receptors . The full length isoform may be cleaved, resulting in release of the free SHBG region which can independently activate Axl . Shed soluble forms of Axl and Mer bind Gas6 and function as decoy receptors . Gas6 induces a variety of responses, including prevention of apoptosis , cell proliferation , platelet-mediated thrombosis , retinal epithelial cell phagocytosis of outer rod segments , inhibition of VEGF-induced endothelial cell chemotaxis , and the differentiation and expansion of NK cell precursors . The affinity of Gas6 for phosphatidylserine likely contributes to its role in promoting the phagocytosis of apoptotic cells . Several of these effects have been shown to require gamma -carboxylation of the Gla domain .
- Formulation:
- Recombinant Human GAS-6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ala678) of Human GAS-6(Accession #NP_000811) fused with a His tag at
- Immunogen:
- Met1-Ala678
- Molecular Weight:
- 71-75 kDa
- Physical State:
- Lyophilized
- Purity:
- ≥90%
- Sequence:
- MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:RP02964
