Recombinant Mouse FLT-3/FLK-2/CD135 Protein
Product Sizes
10 ug
£133.00
RP02957-10UG
20 ug
£181.00
RP02957-20UG
50 ug
£240.00
RP02957-50UG
100 ug
£353.00
RP02957-100UG
500 ug
£1002.00
RP02957-500UG
1000 ug
£1574.00
RP02957-1000UG
About this Product
- SKU:
- RP02957
- Additional Names:
- CD135|FLK-2|FLK2|FLT3|STK1
- Extra Details:
- This protein is a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
- Formulation:
- Recombinant Mouse FLT-3/FLK-2/CD135 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ser544) of mouse FLT-3/FLK-2 (Accession #NP_034359.2) fus
- Immunogen:
- Met1-Ser544
- Molecular Weight:
- 120-140 kDa
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Sequence:
- MRALAQRSDRRLLLLVVLSVMILETVTNQDLPVIKCVLISHENNGSSAGKPSSYRMVRGSPEDLQCTPRRQSEGTVYEAATVEVAESGSITLQVQLATPGDLSCLWVFKHSSLGCQPHFDLQNRGIVSMAILNVTETQAGEYLLHIQSEAANYTVLFTVNVRDTQLYVLRRPYFRKMENQDALLCISEGVPEPTVEWVLCSSHRESCKEEGPAVVRKEEKVLHELFGTDIRCCARNALGRESTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEKGFINATSSQEEYEIDPYEKFCFSVRFKAYPRIRCTWIFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFYAENDDAQFTKMFTLNIRKKPQVLANASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPFPFIQDNIS
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
- Manufacturer's Data Sheet:RP02957
