Recombinant Human Prostatic Acid Phosphatase /ACPP Protein
Product Sizes
10 ug
£145.00
RP01976LQ-10UG
20 ug
£193.00
RP01976LQ-20UG
50 ug
£288.00
RP01976LQ-50UG
100 ug
£431.00
RP01976LQ-100UG
500 ug
£1265.00
RP01976LQ-500UG
1000 ug
£1979.00
RP01976LQ-1000UG
About this Product
- SKU:
- RP01976LQ
- Additional Names:
- ACP3, ACPP,Prostatic acid phosphatase, PAP, EC:3.1.3.2, 5'-nucleotidase, 5'-NT, EC:3.1.3.5, Acid phosphatase 3, Ecto-5'-nucleotidase, Protein tyrosine phosphatase ACP3, EC:3.1.3.48, Thiamine monophosphatase, TMPase, Cleaved into: PAPf39
- Extra Details:
- Prostatic acid phosphatase (PAP, or ACPP), also known as Prostatic Acid Phosphatase /ACPP is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase is synthesized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth factor receptor-2) at the phosphotyrosine (p-Tyr) residues. Injection of the secretory isoform of PAP has potent antinociceptive effects in mouse models of chronic pain. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. Additionally, PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers.
- Formulation:
- Recombinant Human Prostatic Acid Phosphatase /ACPP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys33-Asp386) of Human Prostatic Acid Phosphata
- Immunogen:
- Lys33-Asp386
- Molecular Weight:
- 45-50 kDa
- Purity:
- ≥95%
- Sequence:
- KELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELGEYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETLKSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGVLVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCPLERFAELVGPVIPQDWSTECMTTNSHQGTEDSTD
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
- Manufacturer's Data Sheet:RP01976LQ
