Recombinant Mouse Neuropilin-1/NRP1/VEGF165R/CD304 Protein
Product Sizes
10 ug
£133.00
RP01869-10UG
20 ug
£181.00
RP01869-20UG
50 ug
£240.00
RP01869-50UG
100 ug
£353.00
RP01869-100UG
500 ug
£1002.00
RP01869-500UG
1000 ug
£1574.00
RP01869-1000UG
About this Product
- SKU:
- RP01869
- Additional Names:
- BDCA-4|BDCA4|CD304|CD304 antigen|DKFZp686A03134|DKFZp781F1414|neuropilin 1|Neuropilin-1|Neuropilin1|NP1|NRP|NRP1|transmembrane receptor|Vascular endothelial cell growth factor 165 receptor|VEGF165R
- Extra Details:
- Neuropilin-1 (Npn-1, previously neuropilin; also CD304 or BDCA4 in humans) is a 130140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. The full-length 923 amino acid (aa) mouse Npn-1 contains a 623 aa extracellular domain (ECD) that shares 98% aa identity with rat and 93% aa identity with human, equine, bovine and canine Npn-1 . The ECD contains two N-terminal CUB domains (termed a1a2), two domains with homology to coagulation factors V and VIII (b1b2) and a MAM (meprin) domain (c). At least one splice variant that diverges at aa 587 and lacks the TM domain has been sequenced . This form is potentially a soluble antagonist, based on results from human Npn-1 splice variants . The sema domains of Class III secreted semaphorins such as Sema3A bind Npn-1 a1a2 . Heparin, the heparin-binding forms of VEGF (VEGF165, VEGF-B and VEGF-E), PlGF (PlGF2), and the Cterminus of Sema3 bind the b1b2 region . Npn-1 and Npn-2 share 48% aa identity within the ECD and can form homo- and hetero-oligomers via interaction of their MAM domains . Neuropilins show partially overlapping expression in neuronal and endothelial cells during development. Both Neuropilins act as co-receptors with plexins, mainly plexin A3 and A4, to bind class III semaphorins that mediate axon repulsion . However, only Npn-1 binds Sema3A, and only Npn-2 binds Sema3F . Both are coreceptors with VEGF R2 (also called KDR or Flk-1) for VEGF165 binding . Sema3A signaling can be blocked by VEGF165, which has higher affinity for Npn-1 . Npn-1 is preferentially expressed in developing or remodeling arteries . Npn-1 is also expressed on dendritic cells and mediates DC-induced T cell proliferation .
- Formulation:
- Recombinant Mouse Neuropilin-1/NRP1/VEGF165R/CD304 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe22-Pro856) of Mouse Neuropilin-1/NRP1/VEGF16
- Immunogen:
- Phe22-Pro856
- Molecular Weight:
- 120-140 kDa
- Physical State:
- Lyophilized
- Purity:
- ≥90%
- Sequence:
- FRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGMFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGVLSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYKEWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWISLKEGNKAIIFQGNTNPTDVVLGVFSKPLITRFVRIKPVSWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQADRNWMPENIRLVTSRTGWALPPSPHPYTNEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKTIMDDSKRKAKSFEGNNNYDTPELRTFSPLSTRFIRIYPERATHSGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPTDLDKKNTEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDP
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:RP01869
