Recombinant Mouse R-spondin-1/RSPO1 Protein
Product Sizes
10 ug
£145.00
RP01807-10UG
20 ug
£193.00
RP01807-20UG
50 ug
£288.00
RP01807-50UG
100 ug
£431.00
RP01807-100UG
500 ug
£1240.00
RP01807-500UG
1000 ug
£1954.00
RP01807-1000UG
About this Product
- SKU:
- RP01807
- Additional Names:
- R-spondin|RSPO1|Rspondin
- Extra Details:
- RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.
- Formulation:
- Recombinant Mouse R-spondin-1/RSPO1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser21-Gln265) of mouse R-spondin-1/RSPO (Accession #NP_619624.
- Immunogen:
- Ser21-Gln265
- Molecular Weight:
- 35-45 kDa
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Sequence:
- SRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQEALYLHKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCSKKRKLCGFRKGSEERTRRVLHAPGGDHTTCSDTKETRKCTVRRTPCPEGQKRRKGGQGRRENANRHPARKNSKEPRSNSRRHKGQQQPQPGTTGPLTSVGPTWAQ
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:RP01807
