Recombinant Human BCEI/PS2/TFF1 Protein
Product Sizes
10 ug
£145.00
RP01779-10UG
20 ug
£193.00
RP01779-20UG
50 ug
£288.00
RP01779-50UG
100 ug
£431.00
RP01779-100UG
500 ug
£1240.00
RP01779-500UG
1000 ug
£1954.00
RP01779-1000UG
About this Product
- SKU:
- RP01779
- Additional Names:
- BCEI|D21S21|HP1.A|HPS2|pNR-2|pS2|TFF1
- Extra Details:
- Trefoil Factor 1 (TFF1), also known as pS2, is one of three structurally related secreted proteins that contain trefoil domains. These domains adopt a three-leaved conformation held together by conserved intrachain disulfide bonds. TFF1 is an approximately 7 kDa peptide that plays an important role in epithelial regeneration and wound healing (1). Mature human TFF1 shares 67% amino acid sequence identity with mouse and rat TFF1. It is expressed by goblet cells of the gastric and intestinal mucosa and by conjunctival goblet cells (2-5). TFF1 is a copper-binding protein that can form disulfide-linked homodimers, associate into disulfide-linked complexes with Gastrokine 2, and form non-covalent complexes with the mucin MUC5AC (4, 6-8). Copper enhances TFF1 homodimerization as well as its ability to promote epithelial cell motility, wound healing, and the colonization of H. pylori in stomach and colon epithelia (9, 10). TFF1 is down-regulated during the progression from gastritis to gastric dysplasia to gastric cancer, although it is up-regulated in breast and prostate cancers (11-13). TFF1 inhibits the formation of calcium oxalate crystals, and its excretion in the urine is reduced in patients with kidney stones (14).
- Formulation:
- Recombinant Human BCEI/PS2/TFF1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu25-Phe84) of human BCEI/PS2/TFF1 (Accession #NP_003216.1) fused
- Immunogen:
- Glu25-Phe84
- Molecular Weight:
- 15 kDa
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Sequence:
- EAQTETCTVAPRERQNCGFPGVTPSQCANKGCCFDDTVRGVPWCFYPNTIDVPPEEECEF
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:RP01779
