Recombinant Human Proliferating cell nuclear antigen/PCNA Protein
Product Sizes
10 ug
£145.00
RP01706-10UG
20 ug
£193.00
RP01706-20UG
50 ug
£288.00
RP01706-50UG
100 ug
£431.00
RP01706-100UG
500 ug
£1240.00
RP01706-500UG
1000 ug
£1954.00
RP01706-1000UG
About this Product
- SKU:
- RP01706
- Additional Names:
- ATLD2; Proliferating cell nuclear antigen; PCNA
- Extra Details:
- Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its role as the processivity factor for DNA polymerase delta and epsilon. PCNA tethers the polymerase catalytic unit to the DNA template for rapid and processive DNA synthesis. Two forms of PCNA exist in cells: (i) a detergent-insoluble trimeric form stably associated with the replicating forks during S phase and (ii) a soluble form in quiescent cells in G1 and G2 phases. PCNA forms a toroidal trimer in S phase with replication factor-C (RF-C) and DNA in an ATP-dependent manner and enables the loading of DNA polymerase delta and epsilon onto the complex. The close association of PCNA with kinase complexes involved in cell cycle machinery indicates that PCNA has a regulatory role in cell cycle progression. PCNA also participates in the processing of branched intermediates that arise during the lagging strand DNA synthesis.
- Formulation:
- Recombinant Human Proliferating cell nuclear antigen/PCNA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe2-Ser261) of human Proliferating cell
- Immunogen:
- Phe2-Ser261
- Molecular Weight:
- 35 kDa
- Physical State:
- Lyophilized
- Purity:
- ≥90%
- Sequence:
- FEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:RP01706
