Recombinant Human B7-DC/PD-L2/CD273 Protein
Product Sizes
10 ug
£133.00
RP00988-10UG
20 ug
£181.00
RP00988-20UG
50 ug
£240.00
RP00988-50UG
100 ug
£353.00
RP00988-100UG
500 ug
£1002.00
RP00988-500UG
1000 ug
£1574.00
RP00988-1000UG
About this Product
- SKU:
- RP00988
- Additional Names:
- B7DC,Btdc,CD273,PD-L2,PDCD1L2,PDL2,bA574F11.2,PDCD1LG2
- Extra Details:
- Programmed Death Ligand 2 (PD-L2), also known as B7-DC and butyrophilin-like protein, is a member of the B7 family of proteins that provide signals for regulating T-cell activation and tolerance .PD-L2 is expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites such as rheumatoid arthritis, allergen exposure, and virus infection, PD-L2 is up-regulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand up-regulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.
- Formulation:
- Recombinant Human PD-L2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Pro219) of human PD-L2 (Accession #NP_079515.2) fused with an Fc, 6x
- Immunogen:
- Leu20-Pro219
- Molecular Weight:
- 70 kda
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Sequence:
- LFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHP
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:RP00988
