Recombinant Human B7-H2/ICOSLG/CD275 Protein
Product Sizes
10 ug
£133.00
RP00385-10UG
20 ug
£181.00
RP00385-20UG
50 ug
£240.00
RP00385-50UG
100 ug
£353.00
RP00385-100UG
500 ug
£1002.00
RP00385-500UG
1000 ug
£1574.00
RP00385-1000UG
About this Product
- SKU:
- RP00385
- Additional Names:
- ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS
- Extra Details:
- Inducible co-stimulator ligand (ICOSL) is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.
- Formulation:
- Recombinant Human B7-H2/ICOSLG/CD275 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Asp19-Ser258) of human ICOSLG/B7-H2/CD275 (Accession #O75144) f
- Immunogen:
- Asp19-Thr256
- Molecular Weight:
- 70-100 kDa
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Sequence:
- DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAAT
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:RP00385
