Recombinant Human CD46 Protein
Product Sizes
10 ug
£145.00
RP00279-10UG
20 ug
£193.00
RP00279-20UG
50 ug
£288.00
RP00279-50UG
100 ug
£431.00
RP00279-100UG
500 ug
£1240.00
RP00279-500UG
1000 ug
£1954.00
RP00279-1000UG
About this Product
- SKU:
- RP00279
- Additional Names:
- AHUS2,MCP,MIC10,TLX,TRA2.10,CD46
- Extra Details:
- The recombinant human CD46 consists of 305 amino acids with a molecular weight of 34 kDa. The apparent molecular mass of recombinant human CD46 is about 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.CD46 is also known as MCP and is a type I membrane protein that functions as a cofactor for Complement Factor I-mediated inactivation of complement components C3b and C4b. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2),a disease characterized by uncontrolled complement activation.
- Formulation:
- Recombinant Human CD46 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys35-Asp328) of human CD46 (Accession #NP_758861.1) fused with a 6xHis tag
- Immunogen:
- Cys35-Asp328
- Molecular Weight:
- 55-60 kDa
- Physical State:
- Lyophilized
- Purity:
- ≥90%
- Sequence:
- CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLD
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:RP00279
