Recombinant Human B7-H1/PD-L1/CD274 Protein
Product Sizes
10 ug
£127.00
RP00184-10UG
20 ug
£157.00
RP00184-20UG
50 ug
£223.00
RP00184-50UG
100 ug
£336.00
RP00184-100UG
500 ug
£907.00
RP00184-500UG
1000 ug
£1478.00
RP00184-1000UG
About this Product
- SKU:
- RP00184
- Additional Names:
- B7-H, B7H1, PDL1, PD-L1, hPD-L1, PDCD1L1, PDCD1LG1,CD274,PDL1,B7H1,PD-L1,PDCD1L1,PDCD1LG1, B7-H, CD274 molecule
- Extra Details:
- Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1). PD-L1/B7-H1 is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma.
- Formulation:
- Recombinant Human B7-H1/PD-L1/CD274 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe19-Thr239) of human PD-L1/B7-H1 (Accession #NP_054862.1) fu
- Immunogen:
- Phe19-Thr239
- Molecular Weight:
- Approximately 70 kDa
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Sequence:
- FTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERT
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:RP00184
