Rabbit anti-Human IgM monoclonal antibody
Product Sizes
100 ug
£438.00
RMK0353-100UG
200 ug
£599.00
RMK0353-200UG
500 ug
£1503.00
RMK0353-500UG
1000 ug
£2741.00
RMK0353-1000UG
About this Product
- SKU:
- RMK0353
- Additional Names:
- AGM1|MU|VH
- Application:
- Detection/Quantitation
- Clonality:
- Monoclonal
- Extra Details:
- Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).
- Formulation:
- Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, pH 7.4.
- Immunogen:
- Human IgM Protein
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Secondary Antibodies
- Manufacturer's Data Sheet:RMK0353
