Rabbit anti-Human CD274 monoclonal antibody
Product Sizes
100 ug
£438.00
RMK0231-100UG
200 ug
£599.00
RMK0231-200UG
500 ug
£1503.00
RMK0231-500UG
1000 ug
£2741.00
RMK0231-1000UG
About this Product
- SKU:
- RMK0231
- Additional Names:
- B7-H|B7H1|hPD-L1|PD-L1|PDCD1L1|PDCD1LG1|PDL1
- Application:
- Detection/Quantitation
- Clonality:
- Monoclonal
- Extra Details:
- This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
- Formulation:
- Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, PH 7.4
- Immunogen:
- Recombinant human CD274 Protein
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:RMK0231
