Anti-Human IL-1 beta monoclonal antibody (CAP)
Product Sizes
100 ug
£438.00
RMK0033-100UG
200 ug
£599.00
RMK0033-200UG
500 ug
£1503.00
RMK0033-500UG
1000 ug
£2741.00
RMK0033-1000UG
About this Product
- SKU:
- RMK0033
- Additional Names:
- IL-1|IL1-BETA|IL1beta|IL1F2
- Application:
- CLIA, ELISA
- Clonality:
- Monoclonal
- Extra Details:
- The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
- Formulation:
- Supplied as a 0.2um filtered solution in PBS with 0.05% Proclin300, PH 7.4.
- Host:
- Rabbit
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 117-269 of human IL-1B Beta (NP_000567.1).
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:RMK0033
