Rabbit anti-Human IL-2R monoclonal antibody
Product Sizes
100 ug
£438.00
RM17893-100UG
1000 ug
£2741.00
RM17893-1000UG
About this Product
- SKU:
- RM17893
- Additional Names:
- CD25|IDDM10|IL2R|IMD41|p55|TCGFR
- Application:
- CLIA
- Clonality:
- Monoclonal
- Extra Details:
- The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.
- Formulation:
- Supplied as a 0.2um filtered solution in PBS with 0.05% Proclin300, PH 7.4.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 22-213 of human IL-2R(NP_000408.1)
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:RM17893
