Rabbit anti-Human Cathepsin B monoclonal antibody (DET)
Product Sizes
100 ug
£438.00
RM17875-100UG
500 ug
£1503.00
RM17875-500UG
1000 ug
£2521.00
RM17875-1000UG
About this Product
- SKU:
- RM17875
- Additional Names:
- APPS|CPSB|KWE|RECEUP
- Application:
- ELISA
- Clonality:
- Monoclonal
- Extra Details:
- This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified.
- Formulation:
- Supplied as a 0.2um filtered solution in PBS with 0.05%ProClin 300,PH 7.4.
- Immunogen:
- Recombinant Human Neurogranin
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:RM17875
