Rabbit anti-Chicken IL-10 monoclonal antibody (DET)
Product Sizes
100 ug
£438.00
RM17836-100UG
500 ug
£1503.00
RM17836-500UG
1000 ug
£2521.00
RM17836-1000UG
About this Product
- SKU:
- RM17836
- Additional Names:
- IL-10|interleukin-10
- Application:
- ELISA
- Clonality:
- Monoclonal
- Extra Details:
- Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation
- Formulation:
- Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, pH 7.4.
- Immunogen:
- Recombinant Chicken IL-10 Protein
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Avian
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:RM17836
