Rabbit anti-Human sST2 monoclonal antibody

Product Sizes

100 ug

£438.00

RM17779-100UG

500 ug

£1503.00

RM17779-500UG

1000 ug

£2521.00

RM17779-1000UG

About this Product

SKU:: RM17779
Application:: ELISA
Clonality:: Monoclonal
Extra Details:: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization
Formulation:: Supplied as a 0.2um filtered solution in PBS with 0.05% Proclin300, PH 7.4.
Immunogen:: Recombinant Human sST2 Protein
Isotype:: IgG
Purification:: Affinity Purified
Shipping Conditions:: Dry Ice
Storage Conditions:: -20[o]C
Supplier:: ABclonal Technology
Type:: Antibody: Monoclonal Antibody

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