PE Rabbit anti-Mouse VEGFR3/Flt-4 monoclonal antibody
Product Sizes
2.5 ug
£ POA
A28963-2.5UG
50 ug
£229.00
A28963-50UG
100 ug
£372.00
A28963-100UG
About this Product
- SKU:
- A28963
- Additional Names:
- Chy|Flt-4|VEGFR-3|VEGFR3
- Application:
- Flow Cytometry
- Clonality:
- Monoclonal
- Extra Details:
- Vascular endothelial growth factor C (VEGF-C) and VEGF-D constitute a subfamily of vascularogenic VEGF growth factors. VEGF-C is combined into a 58 kDa molecule, consisting of a VEGF homologous domain (VHD), with N-terminal and C-terminal propeptides on both sides. The precursor protein undergoes covalent dimerization and progressive proteolysis to generate a ligand with enhanced affinity for VEGF R3/Flt-4. The fully processed VEGF-C contains only 21 kDa VHD and can additionally bind and activate VEGF R2/KDR/Flk-1. The fully processed human VEGF-C has 98% identical amino acid sequence to that of mouse and rat VEGF-C. The interaction of VEGF-C with VEGF R3 is crucial for lymphangiogenesis (5-8). VEGF-C and VEGF R3 are usually co-expressed during lymphangiogenesis, embryonic development, and various pathological conditions. Overexpression of VEGF-C in tumor cells can induce tumor lymphocyte proliferation, leading to increased lymph flow and metastasis to regional lymph nodes. It also induces physiological and tumor-specific angiogenesis and sprouting through interaction with VEGF R2.
- Formulation:
- Unmodified
- Host:
- Rabbit
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:A28963
