ABflo[R] 488 Rabbit anti-Human CA125/MUC16 monoclonal antibody
Product Sizes
10 tests
£ POA
A28811-10TESTS
100 tests
£562.00
A28811-100TESTS
200 tests
£883.00
A28811-200TESTS
500 tests
£1389.00
A28811-500TESTS
About this Product
- SKU:
- A28811
- Additional Names:
- CA125
- Application:
- Flow Cytometry
- Clonality:
- Monoclonal
- Conjugate:
- ABflo® 488
- Extra Details:
- Mucin is a large family of molecules that add a protective layer to respiratory epithelial cells to shield them from microorganisms and pollutants in the local environment. Among the known members of this family, some are produced in a cell-type and tissue-specific manner, suggesting that each mucin member has different biological functions. Some members aggregate after secretion to form a gel-like substance covering the epithelial layer. CA125, also known as MUC16, is a mucin protein that may be found in the form of a transmembrane or secreted protein, used for monitoring the progress of treatment for epithelial ovarian cancer. The CA125 molecule is almost certainly a glycoprotein with an o bond. Its size and charge are uneven, and the most likely reason is that its side chains are constantly de-sulfoglycosylated during its life cycle in body fluids. Under natural conditions, it is a very large complex (possibly up to 400,000 daltons). MUC16 is a member of the mucin family, which are high-molecular-weight, O-glycosylated proteins that play an important role in the formation of mucosal barriers and are found on the top surface of epithelial cells. It contains an amino-terminal extracellular domain, a large tandem repeat sequence, and a transmembrane domain with a short cytoplasmic domain. MUC16 is associated with lung cancer and ovarian cancer. It provides a protective lubricating barrier against particles and pathogens on the mucosal surface.
- Formulation:
- Unmodified
- Host:
- Rabbit
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:A28811
