ABflo[R] 488 Rat anti-Mouse CD115/CSF-1R monoclonal antibody
Product Sizes
5 ug
£ POA
A28661-5UG
25 ug
£145.00
A28661-25UG
100 ug
£240.00
A28661-100UG
About this Product
- SKU:
- A28661
- Additional Names:
- CD115|CSF-1R|Csfmr|Fim-2|Fim2|Fms|M-CSF-R|M-CSFR
- Application:
- Flow Cytometry
- Clonality:
- Monoclonal
- Conjugate:
- ABflo® 488
- Extra Details:
- CSF-1R, also known as CD115 and M-CSFR, is a type I transmembrane protein belonging to the platelet-derived growth factor receptor family. The natural ligands for this c-fms (Fms) proto-oncogene product include M-CSF and IL-34. Structural studies of CD115 have described an immunoglobulin (Ig)-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail. Upon activation, the receptor not only undergoes phosphorylation and ubiquitination of its intracellular residues but also induces homodimerization. CD115 directly influences the differentiation and proliferation of tissue macrophages and osteoclasts. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasma cells, conventional dendritic cells, and osteoclasts.
- Formulation:
- Unmodified
- Host:
- Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Isotype:
- IgG2a, kappa
- Molecular Weight:
- 109 kDa
- Purification:
- Affinity Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:A28661
