APC Mouse anti-Human CD192/CCR2 monoclonal antibody
Product Sizes
10 tests
£ POA
A28626-10TESTS
100 tests
£288.00
A28626-100TESTS
2 x 100 tests
£467.00
A28626-2X100TESTS
5 x 100 tests
£1026.00
A28626-5X100TESTS
About this Product
- SKU:
- A28626
- Additional Names:
- CC-CKR-2|CCR-2|CCR2A|CCR2B|CD192|CKR2|CKR2A|CKR2B|CMKBR2|MCP-1-R
- Application:
- Flow Cytometry
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, -2, -3, and -4). Two alternatively spliced variants (CCR2A and CCR2B) were initially described, which differ in their C-terminal cytoplasmic tails. The adhesion of monocytes to arterial endothelium and their subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. Both CCR2 and MCP-1 are implicated in atherosclerotic plaque formation. MCP-1, induced in endothelial cells by modified low-density lipoprotein (LDL), may trigger firm monocyte attachment to the vascular endothelium under flow conditions. Local overexpression of MCP-1 within the vessel wall induces macrophage infiltration and the development of atherosclerotic lesions. Obesity induces a state of chronic inflammation, which is associated with numerous clinically significant complications, including insulin resistance, diabetes mellitus, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 plays a critical role in the development of obesity and the associated inflammation within adipose tissue.
- Formulation:
- Unmodified
- Host:
- Mouse
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Isotype:
- IgG2a, kappa
- Molecular Weight:
- 42kda
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:A28626
