ABflo[R] 488 Rat anti Mouse CD172a/SIRPA Alpha monoclonal antibody
Product Sizes
5 ug
£ POA
A28607-5UG
25 ug
£121.00
A28607-25UG
100 ug
£193.00
A28607-100UG
About this Product
- SKU:
- A28607
- Additional Names:
- Bit, P84, SIRP, SHP-1, CD172a, Ptpns1, SHPS-1, Idd13.2
- Application:
- Flow Cytometry
- Clonality:
- Monoclonal
- Conjugate:
- ABflo® 488
- Extra Details:
- CD172a, also known as SIRPA Alpha, is a type I transmembrane protein featuring an extracellular region with one V-set Ig-like domain and two C-set Ig-like domains, and a cytoplasmic tail containing two immunoreceptor tyrosine-based inhibition motifs (ITIMs) and a proline-rich region. It is expressed by monocytes, macrophages, myeloid cells, and neuronal tissues. Phosphorylation of the SIRPA Alpha ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 (SHP-1) and PTPN11 (SHP-2), leading to the negative regulation of various biological processes. The known ligands for CD172a include CD47, surfactant protein A (SP-A), and surfactant protein D (SP-D).
- Formulation:
- Unmodified
- Host:
- Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Isotype:
- IgG1, kappa
- Molecular Weight:
- 56kDa
- Purification:
- Affinity Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:A28607
