APC Rabbit anti-Human CD114/G-CSFR monoclonal antibody
Product Sizes
10 tests
£ POA
A28578-10TESTS
100 tests
£288.00
A28578-100TESTS
2 x 100 tests
£478.00
A28578-2X100TESTS
5 x 100 tests
£1050.00
A28578-5X100TESTS
About this Product
- SKU:
- A28578
- Additional Names:
- CD114|GCSFR|SCN7
- Application:
- Flow Cytometry
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- The granulocyte colony-stimulating factor receptor (G-CSF-R) is a transmembrane protein composed of an immunoglobulin-like (Ig-like) domain, a cytokine receptor homology (CRH) domain, and three fibronectin type III (FN III) domains. G-CSF-R is expressed across all granulocyte lineages, including progenitor cells, and has also been detected in monocytes, T and B lymphocytes, and non-hematopoietic tissues such as cardiomyocytes and neural stem cells. Its primary ligand is the cytokine granulocyte colony-stimulating factor (G-CSF). Lacking intrinsic tyrosine kinase activity, G-CSF-R undergoes a conformational change upon ligand binding, leading to the activation of downstream signaling pathways including Jak/Stat, PI3K/Akt, and MAPK. G-CSF promotes the differentiation and proliferation of myeloid progenitors into neutrophils. Mutations in the G-CSF-R gene, CSF3R, are associated with multiple disorders, including severe congenital neutropenia (SCN), chronic neutrophilic leukemia (CNL), and atypical chronic myeloid leukemia (aCML).
- Formulation:
- Unmodified
- Host:
- Rabbit
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Isotype:
- IgG
- Molecular Weight:
- 92 kDa
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:A28578
