ALPK1 Rabbit monoclonal antibody
Product Sizes
5 ul
£ POA
A24046-5UL
20 ul
£164.00
A24046-20UL
100 ug
£342.00
A24046-100UG
500 ul
£1532.00
A24046-500UL
1000 ul
£2704.00
A24046-1000UL
About this Product
- SKU:
- A24046
- Additional Names:
- Alpha-kinase 1|ALPK1
- Application:
- ELISA, IHC-Paraffin, Western Blot
- Clonality:
- Monoclonal
- Extra Details:
- A Alpha- Protein Kinase 1, also known as A Alpha- ALPK1 is associated with chronic kidney disease (CKD), myocardial infarction, gout and type 2 diabetes. According to reports, ALPK1 mutations can lead to serious deficits in motor coordination in mice. ALPK1 can enhance the expression of pro-inflammatory cytokines, including IL-1, in cultured human THP1 and human embryonic kidney 293 (HEK293) cells (PMID: 31557402, PMID: 26275947) B Beta, IL-8 and TGF- B Beta 1. The ALPK1 short subtype (108 kDa) is highly expressed in the brain, spinal cord, heart, lungs, spleen, thymus, small intestine, skin, and testes, while detecting skeletal muscle and kidney. ALPK1 isoform (130 kDa) appears in the heart, lungs, thymus, and skin. As a novel innate immune receptor, ALPK1 can recognize bacteria-derived small molecule ADP-heptose and activate the immune response (PubMed: 30111836, PubMed: 30111836)
- Formulation:
- Unmodified
- Host:
- Rabbit
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Isotype:
- IgG
- Molecular Weight:
- 139kDa
- Purification:
- Affinity Purified
- Reactivities:
- Mouse, Rat
- Sequence:
- PDKKGISTSLGILADIFVSMSKTDYEKFKKSPKVNLALLKEFDHHLLSASEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSCSADCPPGMKSVHLCEAKEAFEIGLLTKKDGELVSGKQELHSFIKAAFGLTTVHSRLHGETDAVRAARQLCSEAVGKLYTFSTSPTSQDREGLSQEIMSLISQVKGHLRVQSFPNLDACSYVPESFKCGLDRLILHGHVDFQQILETYSQHHTSVCEVFESTCGNSK
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- ABclonal Technology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:A24046
