Anti-Glycoprotein [MR78]
Product Sizes
1 mg
AB02824-10-27-BT-1MG
About this Product
- SKU:
- AB02824-10-27-BT
- Additional Names:
- GP; GP1; Envelope glycoprotein; GP1 2; Virion spike glycoprotein; Filovirus
- Application:
- Block/Inhibit/Neutralise, ELISA
- Buffer:
- PBS
- translate.label.attr.clone:
- MR78
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- This reformatted human antibody was made using the variable domain sequences of the original Human Fab format for improved compatibility with existing reagents assays and techniques.
- Formulation:
- PBS only.
- Host:
- Human
- Immunogen:
- The original antibody was generated from peripheral blood mononuclear cells of a donor after screening them for Marburg virus (MARV) antigen-specific antibody-secreting cell lines using ELISAs. Cells from wells with supernatants reacting in a MARV antigen ELISA were fused with HMMA2.5 myeloma cells using an established electrofusion technique.
- Purification:
- Purified
- Reactivities:
- Virus
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody recognizes a GP1 epitope conserved across the filovirus family, which likely represents the binding site of their NPC1 receptor. This antibody also blocks binding of the NPC1 domain C to MARV GP. This antibody was also capable of reacting with Ebola virus (EBOV) GPcl that lacked the glycan cap and mucin-like domain (PMID: 25723164).
- Storage Conditions:
- 2-8[o]C, -20[o]C aliquoted. Avoid freeze/thaw cycles.
- Supplier:
- Absolute Antibody
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Ab02824-10.27-BT
