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Antibodies

NCC Antibody: FITC

Product Size(s)
100 ug
£541.00
SPC-402D-FITC-100UG
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
SPC-402D-FITC
Additional Names:
SLC12A3 Antibody, SCYL1 Antibody,CKb10 Antibody, MCP-4 Antibody, MGC17134 Antibody, NCC-1 Antibody, NCC1 Antibody, SCYA13 Antibody, CK-beta-10 Antibody, monocyte chemoattractant protein 4 Antibody, monocyte chemotactic protein 4 Antibody, new CC chemokine 1 Antibody, small inducible cytokine A13 Antibody, small inducible cytokine subfamily A (Cys-Cys) member 13 Antibody, chemokine (C-C) Antibody
Application:
Immunocytochemistry, Immunoelectron Microscopy, Immunofluorescence, Immunohistochemistry, Western Blot
CE/IVD:
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Clonality:
Polyclonal
Conjugate:
FITC
Concentration:
1 mg/ml
Extra Details:
NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis (1). Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC (2). Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension (1). Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat (3).
Host:
Rabbit
Immunogen:
Produced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal
Purification:
Affinity Purified
Reactivities:
Canine, Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C
Supplier:
StressMarq Biosciences
Type:
Antibody: Polyclonal Antibody
Preservative:
0.09% Sodium azide
Immunohistochemistry analysis using Rabbit Anti-NCC Polyclonal Antibody (SPC-402). Tissue: kidney tissue. Species: Rat. Primary Antibody: Rabbit Anti-NCC Polyclonal Antibody (SPC-402) at 1:200. Secondary Antibody: FITC Goat Anti-Rabbit (green).
Western blot analysis of Rat tissue lysates showing detection of NCC protein using Rabbit Anti-NCC Polyclonal Antibody (SPC-402). Primary Antibody: Rabbit Anti-NCC Polyclonal Antibody (SPC-402) at 1:1000.
Immunohistochemistry analysis using Rabbit Anti-NCC Polyclonal Antibody (SPC-402). Tissue: kidney tissue. Species: Mouse. Fixation: paraformaldehyde-fixed paraffin-embedded. Primary Antibody: Rabbit Anti-NCC Polyclonal Antibody (SPC-402) at 1:500 for Overnight at 4°C . Secondary Antibody: Biotinylated Goat Anti-Rabbit IgG at 1:500 for 30 min at RT. Courtesy of: Brigitte Rogge.
Immunohistochemistry analysis using Rabbit Anti-NCC Polyclonal Antibody (SPC-402). Tissue: kidney tissue. Species: Mouse. Fixation: paraformaldehyde-fixed paraffin-embedded. Primary Antibody: Rabbit Anti-NCC Polyclonal Antibody (SPC-402) at 1:1000 for Overnight at 4°C . Secondary Antibody: Biotinylated Goat Anti-Rabbit IgG at 1:501 for 30 min at RT. Courtesy of: Brigitte Rogge.