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KCC2 Antibody, Clone S1-12: Biotin

SKU:
SMC-392D-BI
Additional Names:
Potassium Chloride Cotransporter Antibody, Potassium chloride transporter 5 Antibody, SLC12A5 Antibody, hKCC2 Antibody, S12A5 Antibody, Solute carrier family 12 member 5 Antibody, Electroneutral potassium-chloride cotransporter 2 Antibody, Furosemide-sensitive K-Cl cotransporter Antibody, K-Cl cotransporter 2 Antibody, rKCC2 Antibody, Neuronal K-Cl cotransporter Antibody, KIAA1176 Antibody, Electroneutral potassium chloride cotransporter 2 Antibody, Erythroid K Cl cotransporter 2 Antibody, Furosemide sensitive K Cl cotransporter Antibody, K-Cl cotransporter 2 Antibody, KCC 2 Antibody, Neuronal K Cl cotransporter Antibody, Solute carrier family 12 (potassium chloride transporter) member 5 Antibody, Solute carrier family 12 member 5 Antibody
Application:
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
CE/IVD:
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Clone:
S1-12
Clonality:
Monoclonal
Conjugate:
Biotin
Concentration:
1 mg/ml
Extra Details:
KCC2 is a member of the cation-chloride cotransporter gene family (1). It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain (2, 3). KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord (4). Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior.
Gene Details:
Slc12a5
Host:
Mouse
Immunogen:
Fusion protein amino acids 932-1043 corresponding to rat KCC2
Isotype:
IgG2a
Protein Details:
Q63633
Purification:
Protein G Purified
Reactivities:
Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C
Supplier:
StressMarq Biosciences
Type:
Antibody: Monoclonal Antibody
Size:
100 ug
Specificity:
Detects ~140kDa.
Preservative:
0.09% Sodium azide
Long Description:
Mouse Anti-Rat KCC2 Monoclonal IgG2a
Accession:
NP_599190
Synonyms:
electroneutral potassium-chloride cotransporter 2;furosemide-sensitive K-Cl cotransporter;Kcc2;K-Cl cotransporter 2;neuronal K-Cl cotransporter;neuronal-specific K-Cl cotransporter;solute carrier family 12 (potassium-chloride transporter), member 5;solute carrier family 12 member 5
Price for 100 ug £455.00

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