Piccolo Antibody, Clone 6H9-B6: PerCP
Product Sizes
100 ug
SMC-188D-PCP-100UG
About this Product
- SKU:
- SMC-188D-PCP
- Additional Names:
- Protein piccolo, Aczonin, PCLO, Presynaptic cytomatrix protein, Multidomain presynaptic cytomatrix protein, Piccolo (presynaptic cytomatrix protein), PCLO_HUMAN, ACZ, Pico, Brain-derived HLMN protein, DKFZp779G1236, KIAA0559, Piccolo mouse homolog of Pico
- Application:
- ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 6H9-B6
- Clonality:
- Monoclonal
- Conjugate:
- PerCP
- Concentration:
- 1 mg/ml
- Extra Details:
- Piccolo (also known as Aczonin) is a large, multidomain scaffolding protein localized at the presynaptic active zone. It plays a central role in organizing the cytomatrix at active zones (CAZ) and coordinating synaptic vesicle trafficking, exocytosis, and endocytosis. Piccolo interacts with proteins involved in actin dynamics and clathrin-mediated endocytosis, including Abp1 and dynamin, thereby regulating synaptic vesicle recycling. It is often co-expressed with Bassoon, another CAZ protein, to maintain synaptic integrity and plasticity. Disruption of Piccolo expression or function has been linked to neurodevelopmental and neurodegenerative disorders, including schizophrenia and Parkinson's disease. Its role in synaptic maintenance and plasticity makes Piccolo a promising target for understanding and treating synaptic dysfunction in neurological diseases.
- Host:
- Mouse
- Immunogen:
- Human full length recombinant protein (GenBank ID: BC001304.1)
- Isotype:
- IgG2b, kappa
- Purification:
- Protein G Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~550kDa. No cross-reactivity to Bassoon.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
