ERp57 (GRP58) Antibody, Clone Map.ERp57 (GRP58): ATTO 488
Product Sizes
200 ug
SMC-168B-A488-200UG
About this Product
- SKU:
- SMC-168B-A488
- Additional Names:
- ERp60, ERp61, Grp57, Grp58, P58, PDIA3, PI PLC, 58 kDa glucose regulated protein, 58 kDa glucose-regulated protein, 58 kDa microsomal protein, Disulfide isomerase ER 60, Disulfide isomerase ER-60, Endoplasmic reticulum resident protein 57, Endoplasmic reticulum resident protein 60, ER p57, ER protein 57, ER protein 60, ERp 57, ERp57, Glucose Regulated Protein 58 Kd, GRP 57, GRP 58, GRP57, HsT17083, p58, PDIA 3, PDIA3_HUMAN, Phospholipase C alpha, Protein disulfide isomerase A3, Protein disulfide isomerase family A member 3, Protein disulfide-isomerase A3
- Application:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- RUO
- translate.label.attr.clone:
- Map.ERp57
- Clonality:
- Monoclonal
- Conjugate:
- ATTO 488
- Concentration:
- 1 mg/ml
- Extra Details:
- ERp57, also known as PDIA3, is a thiol-disulfide isomerase involved in protein folding and quality control within the endoplasmic reticulum (ER). In the brain, ERp57 plays a critical role in maintaining proteostasis, particularly under conditions of ER stress-a key feature of neurodegenerative diseases. ERp57 is upregulated in response to misfolded protein accumulation, as seen in Alzheimer's, ALS, and prion diseases. It interacts with calnexin and calreticulin to assist in the proper folding of glycoproteins, including those involved in synaptic function and neuronal survival. Dysregulation of ERp57 impairs the unfolded protein response (UPR), contributing to neuronal dysfunction and cell death. Given its role in mitigating proteotoxic stress, ERp57 is emerging as a potential therapeutic target for enhancing cellular resilience in neurodegeneration.
- Host:
- Mouse
- Immunogen:
- Human recombinant ERp57 (Grp58)
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Bovine, Canine, Guinea Pig, Hamster, Human, Mouse, Non-human Primate, Porcine, Rabbit, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~57kDa.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
