Clcn3 Antibody, Clone N258/5: APC
Product Sizes
100 ug
SMC-408D-APC-100UG
About this Product
- SKU:
- SMC-408D-APC
- Additional Names:
- CIC3, CLC3, CLCN 3, Chloride channel 3, Chloride channel protein 3, Chloride channel, voltage-sensitive 3, Chloride transporter ClC 3, DKFZp564I0463, H(+)/Cl(-) exchange transporter 3, Chloride transporter ClC-3, ClC-3
- Application:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
- CE/IVD:
- RUO
- translate.label.attr.clone:
- N258/5 (Formerly sold as S258-5)
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Concentration:
- 1 mg/ml
- Extra Details:
- ClC-3 (ClCN3) is a voltage-gated chloride/proton exchanger that plays a critical role in regulating endosomal and synaptic vesicle acidification. By mediating Cl-/H⁺ exchange, ClC-3 contributes to vesicle trafficking, neurotransmitter release, and membrane excitability-key processes in neuronal communication and plasticity. In the brain, ClC-3 is expressed in neurons and glial cells, where it influences synaptic vesicle cycling and endolysosomal function. Dysregulation of ClC-3 has been linked to impaired short-term memory, altered neuronal excitability, and neurodegenerative phenotypes in animal models. Its modulation by protein kinase C suggests a role in activity-dependent signaling pathways. Given its involvement in vesicle dynamics and ion homeostasis, ClC-3 is emerging as a potential target in neurodegenerative disease research, particularly in disorders characterized by synaptic dysfunction and lysosomal impairment.
- Host:
- Mouse
- Immunogen:
- Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Detects ~90kDa. Does not cross-react with Clcn4 or Clcn5 (based on KO validation results).
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Monoclonal Antibody
