(D)-PPA 1 Product Size(s) 1 mg £176.00 PP-120 Add to order Added to order Academic Pricing Please contact us for academic pricing. Contact Us About this Product SKU: PP-120 Additional Names: DPPA-1 CAS Number: 1620813-53-7 Extra Details: (D)-PPA 1 is a programmed death protein 1/ programmed death-ligand 1 (PD-1/PD-L1) interaction inhibitor. (D)-PPA 1 binds to PD-L1 with a Kd of 0.51 μM and can inhibit interaction at a concentration of 1 mg/mL in flow cytometry experiments. (D)-PPA 1 is a hydrolysis-resistant D-peptide and can disrupt the PD-1/PD-L1 interaction in vivo, inhibiting tumour growth and prolonging survival time in mouse models. Molecular Weight: 1555.67 Purity: >95% by hplc References: Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671Sun et al (2018) PD-1/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer. Drug Deliv. 25(1) 1746 PMID: 30394118 Sequence: H-(D)-Asn-(D)-Tyr-(D)-Ser-(D)-Lys-(D)-Pro-(D)-Thr-(D)-Asp-(D)-Arg-(D)-Gln-(D)-Tyr-(D)-His-(D)-Phe-OH Shipping Conditions: Ambient Storage Conditions: Store dry, frozen and in the dark Supplier: Isca Biochemicals Size: 1 mg Solubility: Soluble to 2 mg/ml in water Formula: C70H98N20O21 Need Help?