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Proteins and Peptides

(D)-PPA 1

Product Sizes
1 mg
PP-120-1MG
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
PP-120
Additional Names:
(D)-PPA 1, 1620813-53-7, nyskptdrqyhf, DPPA-1, PP-120|DPPA-1
CAS Number:
1620813-53-7
Extra Details:
(D)-PPA 1 is a programmed death protein 1/ programmed death-ligand 1 (PD-1/PD-L1) interaction inhibitor. (D)-PPA 1 binds to PD-L1 with a Kd of 0.51 uM and can inhibit interaction at a concentration of 1 mg/mL in flow cytometry experiments. (D)-PPA 1 is a hydrolysis-resistant D-peptide and can disrupt the PD-1/PD-L1 interaction in vivo, inhibiting tumour growth and prolonging survival time in mouse models.
Immunogen:
Protein-protein interactions
Molecular Weight:
1555.67
Physical State:
Freeze dried solid
Purity:
>95%
References:
<p>Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. <strong>54</strong> 11760 <a href="https://pubmed.ncbi.nlm.nih.gov/26259671/" target="_blank">PMID: 26259671</a></p><p>Sun et al (2018) PD-1/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer. Drug Deliv. <strong>25</strong>(1) 1746 <a href="https://pubmed.ncbi.nlm.nih.gov/30394118/" target="_blank" rel="nofollow">PMID: 30394118</a><br></p>
Sequence:
H-(D)Asn-(D)Tyr-(D)Ser-(D)Lys-(D)Pro-(D)Thr-(D)Asp-(D)Arg-(D)Gln-(D)Tyr-(D)His-(D)Phe-OH
Shipping Conditions:
Blue Ice
Storage Conditions:
Store dry, frozen and in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
Solubility:
Soluble to 2 mg/ml in water
Formula:
C70H98N20O21