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(D)-PPA 1

SKU:
PP-120
Additional Names:
DPPA-1
CAS Number:
1620813-53-7
Extra Details:
(D)-PPA 1 is a programmed death protein 1/ programmed death-ligand 1 (PD-1/PD-L1) interaction inhibitor.  (D)-PPA 1 binds to PD-L1 with a Kd of 0.51 μM and can inhibit interaction at a concentration of 1 mg/mL in flow cytometry experiments. (D)-PPA 1 is a hydrolysis-resistant D-peptide and can disrupt the PD-1/PD-L1 interaction in vivo, inhibiting tumour growth and prolonging survival time in mouse models.
Molecular Weight:
1555.67
Purity:
>95% by hplc
References:

Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671

Sun et al (2018) PD-1/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer. Drug Deliv. 25(1) 1746 PMID: 30394118

Sequence:
H-(D)-Asn-(D)-Tyr-(D)-Ser-(D)-Lys-(D)-Pro-(D)-Thr-(D)-Asp-(D)-Arg-(D)-Gln-(D)-Tyr-(D)-His-(D)-Phe-OH
Shipping Conditions:
Ambient
Storage Conditions:
Store dry, frozen and in the dark
Supplier:
Isca Biochemicals
Size:
1 mg
Solubility:
Soluble to 2 mg/ml in water
Formula:
C70H98N20O21
Price for 1 mg £176.00

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