UFP 101
About this Product
- SKU:
- NO-010
- Additional Names:
- [Nphe1,Arg14,Lys15]nociceptin-NH2, [Nphe1, Arg14, Lys15] N/OFQ NH2|UFP 101, UFP-101, [Nphe1,Arg14,Lys15]nociceptin-NH2, 849024-68-6, [Nphe1, Arg14, Lys15] N/OFQ NH2, NO-010
- CAS Number:
- 849024-68-6
- Extra Details:
- UFP 101 is a potent, selective and competitive antagonist at the nociceptin receptor. UFP 101 binds to nociceptin receptors with high affinity (pKi 10.24) and possesses ~3000 fold selectivity over the classical opioid receptors. UFP 101 is antinociceptive and opposes the action of nociceptin in vivo, with an antinociceptive effect when given i.c.v. while being inactive following spinal administration in mice. UFP 101 also shows antidepressant effects in distinct species and can reduce microvascular inflammation to lipopolysaccharide in vivo.
- Immunogen:
- Nociceptin receptors
- Molecular Weight:
- 1908.19
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Calo et al (2002) [Nphe1,Arg14,Lys15]Nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. Br.J.Pharmacol. <strong>136</strong> 303 <a href="https://pubmed.ncbi.nlm.nih.gov/12010780/" target="_blank" rel="nofollow">PMID: 12010780</a></p><p>Calo et al (2005) UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor. CNS Drug Rev. <strong>11</strong>(2) 97 <a href="https://pubmed.ncbi.nlm.nih.gov/16007234/" target="_blank" rel="nofollow">PMID: 16007234</a></p><p>Brookes et al (2013) The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo. PLoS One 8(9) e74943 <a href="https://pubmed.ncbi.nlm.nih.gov/24086402/" target="_blank" rel="nofollow">PMID: 24086402</a></p>
- Sequence:
- Bn-Gly-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Arg-Lys-Asn-Gln-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C82H138N32O21
