DRB
Product Sizes
10 mg
10-2047-10MG
10 mM (in 1 ml DMSO)
10-2047-10MM(IN1MLDMSO)
50 mg
10-2047-50MG
About this Product
- SKU:
- 10-2047
- Additional Names:
- 5,6-Dichlorobenzimidazole riboside|NSC 401575
- CAS Number:
- 53-85-0
- Extra Details:
- A classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 uM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 uM. 3 Suppresses the SIRT1/CK2A Alpha pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5
- Immunogen:
- Kinase|RNA
- Molecular Weight:
- 319.14
- Physical State:
- Solid
- Purity:
- 98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
